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pentobarbital will reduce the extent or effect of temsirolimus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will enhance the amount or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.Check Closely (1)pentobarbital will lessen the level or effect